解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.11.018
更新日期:2018-01-25 00:00:00
abstract::KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.01.006
更新日期:2018-01-25 00:00:00
abstract::The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.11.043
更新日期:2018-01-25 00:00:00
abstract::Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.12.012
更新日期:2018-01-11 00:00:00
abstract::Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot. ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.12.039
更新日期:2018-01-11 00:00:00
abstract::Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.11.034
更新日期:2018-01-11 00:00:00
abstract::Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of human mammary epithelial organoids. Using this protocol, >100 primary and metastatic BC organoid lines were generated, broadly recapitulating t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.11.010
更新日期:2018-01-11 00:00:00
abstract::The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolvin...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.11.024
更新日期:2017-12-14 00:00:00
abstract::Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (L...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.10.001
更新日期:2017-11-30 00:00:00
abstract::In this issue of Cell, two articles show that tumor-specific changes in HLA-mediated antigen presentation affect tumor immunogenicity and may play a role in shaping cancer cell survival. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.11.012
更新日期:2017-11-30 00:00:00
abstract::Activating mutations of FLT3 occur in about 30% of acute myeloid leukemia (AML) cases and are associated with relapse and poor prognosis. Midostaurin is the first drug approved for AML since 2000, and the first multi-kinase inhibitor approved for the FLT3-mutant subtype. To view this Bench to Bedside, open or download...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.11.007
更新日期:2017-11-16 00:00:00
abstract::The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.10.028
更新日期:2017-11-02 00:00:00
abstract::Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deplo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.034
更新日期:2017-11-02 00:00:00
abstract::The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic changes in tumors from 68 patients with advanced melanoma, who progressed on ipilimumab or were ipilimumab-naive, before and after nivolumab initiation (CA209-038 study). Tumors were analyzed by...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.028
更新日期:2017-11-02 00:00:00
abstract::The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 path...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.046
更新日期:2017-10-19 00:00:00
abstract::Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.008
更新日期:2017-10-19 00:00:00
abstract::The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.08.051
更新日期:2017-10-19 00:00:00
abstract::MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.08.035
更新日期:2017-10-05 00:00:00
abstract::Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have dev...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.09.021
更新日期:2017-10-05 00:00:00
abstract::Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcripti...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.09.010
更新日期:2017-09-21 00:00:00
abstract::AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.045
更新日期:2017-09-07 00:00:00
abstract::Regulatory T cells (Tregs) play a pivotal role in the inhibition of anti-tumor immune responses. Understanding the mechanisms governing Treg homeostasis may therefore be important for development of effective tumor immunotherapy. We have recently demonstrated a key role for the canonical nuclear factor κB (NF-κB) subu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.08.004
更新日期:2017-09-07 00:00:00
abstract::Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infecti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.030
更新日期:2017-08-24 00:00:00
abstract::Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.08.003
更新日期:2017-08-24 00:00:00
abstract::Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that prevent the ascent of bladder microbes. Here, we show that the regional hypersalinity, required for the kidney's urine-conce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.022
更新日期:2017-08-24 00:00:00
abstract::Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their epidermal and muscle stem cells retain a robustly rhythmic core circadian machinery. However, the osci...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.035
更新日期:2017-08-10 00:00:00
abstract::Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.06.010
更新日期:2017-07-27 00:00:00
abstract::The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.07.017
更新日期:2017-07-27 00:00:00
abstract::Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.06.037
更新日期:2017-07-13 00:00:00
abstract::Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.06.015
更新日期:2017-07-13 00:00:00
abstract::Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.047
更新日期:2017-06-29 00:00:00
abstract::The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.06.026
更新日期:2017-06-29 00:00:00
abstract::Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging. Here, through screening 3,983 Escherichia coli mutants, we discovered that 29 bacterial genes, when deleted, increase l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.036
更新日期:2017-06-15 00:00:00
abstract::ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor apolipoprotein A-I (apoA-I) for generation of nascent high-density lipoprotein (HDL). Mutations of human ABCA1 are associated with Tangier disease and familial HDL defi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.020
更新日期:2017-06-15 00:00:00
abstract::Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays. They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic assembly of protein called the pericentriolar material (PCM). To study how PCM forms a spherical compartment that nucleates microtubules, we reconstituted P...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.028
更新日期:2017-06-01 00:00:00
abstract::The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.05.014
更新日期:2017-05-18 00:00:00
abstract::In two companion reports, the TRACERx consortium investigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer. The studies highlight the prognostic value of copy-number heterogeneity assessment in tumor biopsies and circulating tumor DNA detection in plasma and suggest that tracking the evo...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.05.001
更新日期:2017-05-18 00:00:00
abstract::Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) structure of the human spliceosome just before exon ligation (the C∗ complex) at an average resolution of 3.76 Å. The splicing factor Prp17...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.04.033
更新日期:2017-05-18 00:00:00
abstract::Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.04.008
更新日期:2017-05-04 00:00:00
abstract::To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.04.014
更新日期:2017-05-04 00:00:00